Describe the lock & key hypothesis of enzyme action?
Fischer's lock and key hypothesis of enzyme activity state that if the proper key fits in the right lock, the lock can be opened; otherwise, the lock cannot be unlocked. To interpret the preceding in the context of enzyme function, it is assumed that molecules have precise geometric forms. Proteins can operate as enzymes because their form creates a space configuration into which other molecules can fit. The compounds that are acted on by enzymes are referred to as enzyme substrates. Only substrate molecules with the proper geometric shape can fit into the active site of the enzymes, according to the aforementioned premise. However, under certain conditions, other molecules that are similar to the substrate might potentially bind with the active site of the enzyme. In such instances, molecules may compete with the substrate, causing the process to slow or cease. This is known as competitive inhibition.
