What is the significance of juxtaglomerular apparatus (JGA) in kidney function?
Juxtaglomerular equipment (JGA) is a complicated shape made of some cells of glomerulus, distal tubule, and afferent and efferent arterioles. It is placed in a specialized area of a nephron, in which the afferent arteriole and the distal convoluted tubule (DLT) are available in direct touch with every other. The juxtaglomerular equipment carries specialized cells of the afferent arteriole referred to as juxtaglomerular cells. These cells incorporate the enzyme renin which could feel blood stress. When glomerular blood flow (or glomerular blood strain or glomerular filtration price) decreases, it turns on juxtaglomerular cells to launch renin. Renin converts the angiotensinogen in blood into angiotensin I and in addition into angiotensin II. Angiotensin II is a effective vasoconstrictor that will increase the glomerular blood strain and filtration fee. Angiotensin II additionally stimulates the adrenal cortex of the adrenal gland to provide aldosterone. Aldosterone will increase the fee of absorption of sodium ions and water from the distal convoluted tubule and the amassing duct. This additionally results in an boom in blood stress and glomerular filtration price. This mechanism, called renin-angiotensin mechanism, in the end ends in an multiplied blood strain.
