Write a short note on: (i) Production of human growth hormone by E. coli.
Production of human growth hormone by E. coli. The Human growth hormone is produced commercially by transgenic Escherichia coli. The pituitary gland of humans produces growth hormones that regulate growth and development. However, in children stunted growth occurs due to deficiency of the hormone called pituitary dwarfism. For this, the hGH is now available as a recombinant protein. The high-coding DNA sequence is linked with the bacterial signal sequence of E. coli. The hGH is secreted into the periplasmic space of bacterial cells by the signal peptides wherefrom the protein is purified.
