Explain the chemical events taking place during clotting /coagulation of blood.
An injury or a trauma stimulates the plate- 195 lets in the blood to release certain factors which activate the mechanism of coagulation. Clot or coagulam informed mainly of network threads called fibrils in which dead and damaged formed elements of blood are trapped. Fibrins are formed by the conversion of inactive fibrinogens in the plasma by the enzyme thrombin. Thrombins, in turn are formed from another inactive substance present in the plasma called prothrombin. An enzyme complex, thrombokinase, is required for the above reaction which is formed by a series of linked enzymic reactions involving a number of factors present in the plasma in an inactive state. Calcium ions play a very important role in clotting.
