How does pepsinogen change into its active form?
Pepsinogen is secreted by the chief cell of the stomach; it is an inert enzyme. Pepsinogen is first split by hydrochloric acid into active form pepsin. Then the pepsin itself continues to activate all the additional pepsinogen. This type of activation is known as an autocatalytic reaction. Pepsin is the enzyme that is involved in the hydrolysis of large protein molecules into small molecules of proteases and peptones.
