4. Why Is Buprenorphine Less Addictive Than Other Opioids (like Fentanyl) - Is It Explainable By Its Strength Of Binding To The Common Receptor, Or?
Buprenorphine is what is referred to as a partial agonist - i.e. it binds to the receptor but even at its maximum cannot give as much of an effect as a full agonist (such as morphine) - it is, thus, also a partial antagonist (partially inhibits the actions of full agonists).