48.A localised inflammatory response appears at the site of infection causes redness, swelling, pain and heat due to certain chemicals, they are A. Histamine and prostaglandins B. Cerumen and mucus C. Histamine and cerumen D. Prostaglandins and cerumen
Option A. In localized infection, redness and heat are due to increased blood flow at body core temperature to the inflamed site, swelling is caused by accumulation of fluid, pain is due to the release of chemicals such as prostaglandin and histamine that stimulate nerve endings.Histamine are mono-amine produced from mast cells and basophils these are stored in preformed granules, and is released to a number of stimuli these lead to arterial dilation and increased venous permeability. Prostaglandins are eicosaniod produced from mast cells they leads to vasodilation, fever and pain. Hence, localized inflammatory response at the sight of infection producing redness, swelling, pain and heat is due to prostaglandin and histamine.
