The first dicarboxylic acid in Krebs’ cycle is : (a) Isocitic acid (b) Pyruvic acid (c) Oxalo acetic acid (d) 𝛼 – ketoglutaric acid
Option D. The first 5 carbon dicarboxylic acid in Krebs' cycle is α-ketoglutaric acid. The α-ketoglutarate that accumulates when α-ketoglutarate dehydrogenase is inhibited can be used in nitrogen metabolism as a precursor for several amino acids and the purine bases. α−ketoglutarate→Glutamate→Otheraminoacids→Purines
