Which enzyme of glycolysis controls the rate of reaction? (a) Phosphofructokinase (b) Aldolase (c) Isomerase (d) Phosphoglyceraldehyde dehydrogenase
Option A. The rate-limiting step in glycolysis is the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, which is catalyzed by the enzyme phosphofructokinase. So, phosphofructokinase is called a rate-limiting enzyme in glycolysis. It is an energetically favorable step, irreversible and a different pathway must be used to do the reverse conversion during gluconeogenesis. This makes the reaction a key regulatory point.
