Which one of the following chemicals is associated with muscle fatigue? A)Uric acid B)Acetic acid C)Pyruvic acid D)Lactic acid
Option D) Muscle fatigue refers to the decline in muscle force generated over sustained periods of activity. Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue. Lactic acid accumulation leads to increased intracellular hydrogen ion (H+) concentration that leads to a weaker contraction.
